Open Questions: RNA Biology

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Prerequisites: Molecular biology and genetics

See also: Gene expression and regulation

Introduction

MicroRNA

RNA interference

Ribozymes

Riboswitches

Antisense RNA

RNA degradation


Recommended references: Web sites

Recommended references: Magazine/journal articles

Recommended references: Books

Introduction



Recommended references: Web sites

Site indexes


Sites with general resources

miRNA Resource
A resource page with a number of links to information about miRNA, provided by Ambion, Inc.. There are a number of useful articles, and information resources. A good place to start is this graphic Introduction to microRNA.

Surveys, overviews, tutorials

Gene regulation by microRNAs
Good single-page overview of microRNA.
Scientists Develop New Technique for Silencing Human Genes
May 2001 Scientific American news article about use of RNA interference for gene silencing.


Recommended references: Magazine/journal articles

Catalyzing RNA
Sean P. Ryder
The Scientist, September 2010
Once thought to be a biological rarity, self-cleaving RNA enzymesóribozymesóare being discovered in increasing numbers, thanks to new search tools. Now, in addition to studying their unusual chemical properties, scientists will be able to identify ribozymes in useful model organisms; bringing the field one step closer to defining whether these catalytic RNAs have a broad function in gene regulation.
Cancer's little helpers
Tina Hesman Saey
Science News, August 28, 2010
Tiny pieces of RNA may turn cells to the dark side.
Translation Revelation
Jef Akst
The Scientist, December 2009
More findings confirm that small RNAs work in mysterious ways.
Now Showing: RNA Activation
Elie Dolgin
The Scientist, May 1, 2009
RNA is supposed to silence genes, not boost gene expression. So why are scientists seeing just that?.
Micromanagers
Tina Hesman Saey
Science News, March 1, 2008
New classes of RNAs emerge as key players in the brain.
MicroRNA Target Practice
Douglas Steinberg
The Scientist, June 20, 2005
Computers suggest thousands of binding sites, but experimental support is missing.
MicroRNA Shows Macro Potential
Douglas Steinberg
The Scientist, June 16, 2003
Researchers seek targets and functions of a large new class of small RNAs.
Biological dark matter
John Travis
Science News, January 12, 2002
Newfound RNA suggests a hidden complexity inside cells.


Recommended references: Books


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