Open Questions: Antibiotics

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See also: Infectious diseases -- Microbiology

Introduction

Antibiotics

Antibiotic resistance

Antivirals


Recommended references: Web sites

Recommended references: Magazine/journal articles

Recommended references: Books

Introduction



Recommended references: Web sites

Site indexes


Sites with general resources

Medline Plus: Antibiotics
General page of information and links related to antibiotics, provided by Medline Plus. Contents include recent news, links to related topics, and overviews.
NeLI Antimicrobial Resistance Website
Information provided by the (UK) National electronic Library of Infection on antibiotic resistance. In addition to general information, there are news items, lists of additional resources, and discussions of preventing resistance.
Antibiotic Resistance
The site provides general background information and a list of frequently-asked questions, maintained by the U. S. Centers for Disease Control and Prevention.
Antibiotic Resistance
A page with information on some topics on antibiotic resistance, provided by the U. S. Food and Drug Administration.


Surveys, overviews, tutorials

How to cure diseases before they have even evolved
August 2009 New Scientist article. "It could be the biggest breakthrough since the discovery of penicillin: a new generation of antivirals that work against a huge range of viruses, including ones that don't exist yet."
Scientists to squeeze antibiotics out of sea sponge
October 2000 news article about possible antibiotics that could be obtained from sponges.
Why is it only recently that antibiotic-resistant bacteria have become the focus of attention and alarm?
Questions about antibiotic-resistant bacteria answered by several experts in a Scientific American "Ask the Experts" article.


Recommended references: Magazine/journal articles

Squashing Superbugs--The Race for New Antibiotics
Christopher T. Walsh; Michael A. Fischbach
Scientific American, July 2009
Scientists are using new tools and tactics in the race to discover novel antibiotics.
Trial Phage
Josh Brown
Seed Magazine, February-March 2006
Battling Evolution to Fight Antibiotic Resistance
Monya Baker
The Scientist, October 2005
Fresh approaches could aid existing drugs.
How to Find New Antibiotics
Jo Handelsman
The Scientist, October 2005
Metagenomics could be the way to mine the soil beneath our feet.
Behind Enemy Lines
K. C. Nicolaou; Christopher N. C. Boddy
Scientific American, May 2001, pp. 54-61
By now it is well known to the general public that many disease-causing bacterian are increasingly resistant to existing antibiotics. All antibiotics work by disrupting some function within a bacterial cell. New knowledge of bacterial genomes should make it possible to learn many new ways to ihibit bacterial cell function and hence to stay ahead of the development of resistance in bacteria.
The Challenge of Antibiotic Resistance
Stuart B. Levy
Scientific American, March 1998, pp. 46-53
Many types of bacteria are developing resistance to many or all currently available antibiotics, because of the ease with which bacteria transmit genetic mutations favorable to resistance. Better control of antibiotic use is one approach to dealing with the problem.
Antibiotic Resistance
Carlos F. Amábile-Cuevas; Maura Cárdenas-Garc&iactute;a; Maurico Ludgar
American Scientist, July-August 1995, pp. 320-329
Antibiotics work through a variety of mechanisms, and bacteria have developed genetic mutations to combat most of these. The rapid spread of genetic resistanct to antibiotics is a serious problem.


Recommended references: Books


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