Open Questions: Proteomics
See also: Protein chemistry and biology
Open Directory Project: Proteomics
- Categorized and annotated links. A version of this
list is at
Google, with entries sorted in "page rank" order. May also be
Sites with general resources
Nature: Proteomics Technology Feature
- Collection of articles, papers, and other materials
from Nature related to
The Post-Genome Project
- August 2001 Scientific American article by Karen Hopkin,
subtitled, "Whether The Human Proteome Will Be Successfully Mapped In
Three Years Depends On How You Define 'Proteome'".
Human Protein Reference Database
- "The Human Protein Reference Database represents a
centralized platform to visually depict and integrate
information pertaining to domain architecture, post-translational
modifications, interaction networks and disease association for
each protein in the human proteome."
The Human Proteome Organisation
- HUPO's mission is to consolidate and coordinate activities of
other proteome organizations, to promote scientific and
educational activities related to proteomics technologies, and
to help disseminate knowledge of the proteome of humans and other
organisms. The site includes
among a number of other resources.
Surveys, overviews, tutorials
Protein crystallography: the human genome in 3-D
- May 1998
article, by Naomi Chayen and John Helliwell.
"Recent developments in X-ray crystallography at synchrotron
radiation sources and progress in the production of good-quality
protein crystals are leading to important advances in our
knowledge of protein structure and function."
An Insoluble Problem?
Robert Michael Stroud
The Scientist, May 2011
- The challenges of crystallizing membrane proteins - and
how they're being overcome.
- The Proteomics Payoff
Technology Review, October 2001, pp. 54-60
- Now that the human genome is mapped, the problem is to understand
exactly what identified genes do. Such research is known as functional
genomics or -- insofar as it is largely the study of the proteins
that genes encode -- proteomics. This work currently involves
listing all identifiable proteins (collectively known as the
"proteome") and their interactions. As if that weren't a difficult
enough task (given that the total number of proteins isn't
known even approximately), a "global understanding" of the proteome
may be even harder to achieve.
- The Protein Hunters
David Ewing Duncan
Wired, April 2001, pp. 164-171
- Building on the database of information built by the Human
Genome Project, researchers and entrepreneurs are preparing to
mount a much larger effort in the field of "proteomics" to
develop a wide variety of new medicines.
- The Next Wave of the Genomics Business
Technology Review, July/August 2000, pp. 46-56
- The field is called "structural genomics" or "functional
genomics". What it's really about is determining the structure and
function of proteins that genes code for. Highly automated techniques
are being developed to allow laboratories to determine the structures
of hundreds of proteins per year.
- The Next Genome Project
Technology Review, May/June 1998, pp. 51-53
- Mapping the human genome is only the first step. Even more
important is the field of proteomics -- figuring out the interactions
among the proteins coded for by the genes.
Copyright © 2002 by Charles Daney, All Rights Reserved